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X-ray-induced chromosome aberrations in Down lymphocytes: an explanation of their increased sensitivity

Journal Article · · Environ. Mutagen.; (United States)
Unstimulated lymphocytes from individuals with Down Syndrome (trisomy 21) are more sensitive to the induction of dicentric and ring aberrations by X rays than normal lymphocytes. Several explanations involving the more rapid rejoining of X-ray--induced lesions in Down cells have been offered. It is shown here that the repair of the DNA damage converted into chromosome aberrations is more rapid in Down cells than normal cells. This more rapid repair results in a higher probability of producing chromosomes aberrations, and hence higher aberration frequencies in Down than normal cells.
OSTI ID:
5363793
Journal Information:
Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 3:1; ISSN ENMUD
Country of Publication:
United States
Language:
English

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Related Subjects

550900 -- Pathology
560115* -- Radiation Effects on Biochemicals-- In Man-- (-1987)
560151 -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL PATHWAYS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
CONGENITAL MALFORMATIONS
CONNECTIVE TISSUE CELLS
DISEASES
DNA
DOWNS SYNDROME
ELECTROMAGNETIC RADIATION
HEREDITARY DISEASES
IONIZING RADIATIONS
KINETICS
LEUKOCYTES
LYMPHOCYTES
MALFORMATIONS
MATERIALS
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PATHOLOGY
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
REACTION KINETICS
RECOVERY
REPAIR
SOMATIC CELLS
X RADIATION