Assessment of the male reproductive system in the preweaning rat following Mn/sub 3/O/sub 4/ exposure

Journal Article · Mon Dec 31 23:00:00 EST 1984 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398509530660· OSTI ID:5434246

Laskey, J W; Rehnberg, G L; Hein, J F; Laws, S C; Edens, F W

Long-Evans rat pups were dosed orally from birth to 21 d with particulate mn/sub 3/O/sub 4/ to obtain a daily dose of 0, 71, or 214 ..mu..g Mn/body weight . d. Assessments of the hypothalamic, pituitary, or testicular functions were determined by measuring the endogenous or stimulated serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and/or testosterone (T) at 21 or 28 d of age. Body, testes, and seminal vesicles weight and tissue concentrations of Mn were also evaluated. Only slight Mn treatment effects were seen in body and testes weights. No effects were seen either on unstimulated or stimulated FSH or LH serum concentrations. Although no Mn treatment effects were seen on endogenous or 2 h human chorionic gonadotropin (hCG) stimulate serum T concentrations, there was a reduction in the serum T following 7 d of hCG stimulation. The hypothalamic Mn concentrations in animals with these reproductive effects were three times those where alterations in the dopaminergic pathway have been reported. However, no indication of hypothalamic or pituitary malfunction was found. These results suggest that the site of Mn damage that causes depression of sustained serum T concentration is in the testicular Leydig cell.

• Research Organization: Environmental Protection Agency, Research Triangle Park, NC
• OSTI ID: 5434246
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 15:2; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANDROGENS
ANDROSTANES
ANIMALS
BIOLOGICAL FUNCTIONS
BIOLOGICAL PATHWAYS
BLOOD SERUM
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
DATA
ELEMENTS
ENDOCRINE GLANDS
EXPERIMENTAL DATA
FSH
FUNCTIONS
GLANDS
GONADOTROPINS
HCG
HORMONES
HYDROXY COMPOUNDS
HYPOTHALAMUS
INFORMATION
INHIBITION
KETONES
LH
MAMMALS
MANGANESE
MANGANESE COMPOUNDS
MANGANESE OXIDES
METALS
NERVOUS SYSTEM
NUMERICAL DATA
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PARTICLES
PARTICULATES
PEPTIDE HORMONES
PITUITARY GLAND
PITUITARY HORMONES
RATS
RODENTS
STEROID HORMONES
STEROIDS
TESTOSTERONE
TOXICITY
TRANSITION ELEMENT COMPOUNDS
TRANSITION ELEMENTS
VERTEBRATES