Alterations in bone metabolism in the rat induced by manganese (Mn) and copper (Cu) deficiencies

Conference · Sat Mar 01 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5430402

Strause, L; Glowacki, J; Saltman, P

Female rats raised from weaning on diets low in both Mn and Cu (L) or deplete in Mn alone (D) developed bone anomalies characterized by decreased radiographic bone density, decreased bone calcium (Ca), Cu, and Mn, and increased serum Ca. The authors used an in vivo ectopic model of bone formation (BF) with demineralized bone particles (DBP), and of bone resorption (BR) with mineral-containing bone particles (BP), to define the effects of Mn and Cu on bone cells. Subcutaneous implantation of DBP and BP into test rats permitted the separate evaluation of BF and BR, respectively. There was significantly less resorption of normal BP by L and D rats than controls (C) (15.4%, 12.4%, and 46.2%, respectively). Normal DBP failed to induce BF in D rats 17 weeks after implantation and was delayed in L rats. C rats showed cartilage formation two weeks after implantation and mature bone 17 weeks after implantation. The effect of Mn and Cu intake on bone matrix was tested by implanting into normal rats BP prepared from the test rats. BP prepared from L and D rats was resorbed to a greater extent than BP prepared from C rats (43.0%, 41.6%, and 34.0%, respectively). The effects of long-term dietary Mn and Cu deficiencies on bone cell metabolism include: decreased bone resorption, production of more labile bone, and decreased synthesis of organic matrix.

• Research Organization: Univ. of California, San Diego, La Jolla
• OSTI ID: 5430402
• Report Number(s): CONF-8604222-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARTILAGE
CONNECTIVE TISSUE
COPPER
DENSITY
ELEMENTS
IMPLANTS
MAMMALS
MANGANESE
METABOLISM
METALS
NUTRITIONAL DEFICIENCY
ORGANS
PHYSICAL PROPERTIES
RATS
RODENTS
SKELETON
TISSUES
TRANSITION ELEMENTS
VERTEBRATES