Relative accretion of /sup 99m/Tc-polyphosphate by forming and resorbing bone systems in rats: its significance in the pathologic basis of bone scanning

Conference · Sun Feb 01 04:00:00 EST 1976 · J. Nucl. Med., v. 17, no. 2, pp. 93-97

OSTI ID:4065522

Garcia, D A; Tow, D E; Kapur, K K; Wells, H

The relative roles of osteogenesis and osteolysis in the production of positive radionuclide images of skeletal lesions were investigated. The uptake of /sup 99m/Tc-polyphosphate (Tc-PP) by each process was measured in an animal model that permitted bone formation and resorption to be studied independently. Ten rats received intramuscular implants of bone-forming demineralized matrix (DM) and resorbing devitalized bone (DV). Radiographs and Tc-PP scintiscans were made each week thereafter. At 6 to 10 weeks, the implants and normal bone samples were removed, counted for /sup 99m/Tc, and examined histologically. The uptake of Tc-PP by DM implants was first detected on images made 3 weeks after implantation, and by DV implants, 1 to 2 weeks later. Serial radiography showed progressive calcification of DM and resorption of DV implants. Microscopic examinations of undecalcified sections, stained with a modified Goldner preparation, revealed vital-bone formation in the DM implants and osteoclastic resorption in the DV. Activity counts per gram of DM and DV implants were, respectively, 200 percent and 90 percent that of normal bone. Since only the bone-forming system (DM) accumulated Tc-PP at greater than normal concentrations, this study indicates that positive bone images of osteolytic lesions solely reflect compensatory osteogenic responses. (auth)

• Research Organization: Veterans Administration Hospital, West Roxbury, MA
• NSA Number: NSA-33-023644
• OSTI ID: 4065522
• Conference Information: Journal Name: J. Nucl. Med., v. 17, no. 2, pp. 93-97
• Country of Publication: United States
• Language: English

Related Subjects

*BONE TISSUES-- PHYSIOLOGY
*SCINTISCANNING-- TECHNETIUM 99
*SKELETON-- SCINTISCANNING
550601* --Biomedical Sciences
Basic Studies--Medicine-- Unsealed Radionuclides in Diagnostics
ISOMERIC NUCLEI
N48830* --Life Sciences--New Tracer Techniques--Other
PHOSPHATES
RATS