Correlations between uptake of technetium, calcium, phosphate, and mineralization in rat tibial bone repair

Journal Article · Sat Dec 01 04:00:00 EST 1990 · Journal of Nuclear Medicine; (USA)

OSTI ID:6210050

Shani, J; Amir, D; Soskolne, W A; Schwartz, Z; Chisin, R; Sela, J ^[1]

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1. Hebrew Univ.-Hadassah School of Medicine, Jerusalem (Israel)

Technetium-99m-({sup 99m}Tc) phosphates are extensively used for detection of bone formation and resorption. The present is a study of {sup 99m}Tc incorporation during bone remodeling. Uptake of {sup 99m}Tc-labeled phosphate was studied in an animal model of primary osteogenesis following tibial marrow injury and incorporation was correlated to that of calcium-47 ({sup 47}Ca), phosphorus-32 ({sup 32}P), and with matrix vesicle calcification. Isotope uptake on Day 6 in the whole bone was increased compared to controls. On this day, an increase in vesicular diameter and distance from the calcified front was previously observed. Technetium-99m-labeled phosphates were detected only in the organic phase. Phosphorus-32 and {sup 47}Ca were detected in both organic and inorganic phases. It is suggested that {sup 99m}Tc serves as a specific marker to the anabolic phase of remodeling. Increased incorporation of {sup 99m}Tc during bone healing indicates enhanced organic matrix formation and not calcification.

• OSTI ID: 6210050
• Journal Information: Journal of Nuclear Medicine; (USA), Journal Name: Journal of Nuclear Medicine; (USA) Vol. 31:12; ISSN 0161-5505; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
560162 -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MARKERS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CALCIUM
CALCIUM 47
CALCIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
ELEMENTS
EVEN-ODD NUCLEI
HEALING
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METALS
MINERALIZATION
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXYGEN COMPOUNDS
PHOSPHATES
PHOSPHORUS COMPOUNDS
RADIOISOTOPES
RATS
RECOVERY
REPAIR
RODENTS
SKELETAL DISEASES
SKELETON
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES