Heterotopic new bone formation causes resorption of the inductive bone matrix

Journal Article · Wed Aug 01 04:00:00 EDT 1990 · Clinical Orthopaedics and Related Research; (USA)

DOI:https://doi.org/10.1097/00003086-199008000-00043· OSTI ID:6522249

Nilsson, O S; Persson, P E; Ekelund, A ^[1]

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1. Karolinska Institute and Hospital, Stockholm (Sweden)

The bone matrix of growing rats was labeled by multiple injections of 3H-proline, and demineralized bone matrix (DBM) was prepared. The DBM was allotransplanted heterotopically into growing rats. New bone formation was induced in and around the implants. The new bone formation was accompanied by a decrease in the content of 3H; 20 and 30 days after implantation, 72% and 46%, respectively, of the activity remained in the implants. Daily injections of indomethacin (2 mg/kg) inhibited calcium uptake by about 20% at 20 and 30 days and inhibited the release of 3H from the DBM to a similar degree. Heterotopic bone induction by DBM is accompanied by matrix resorption, and inhibition of the new bone formation decreases the resorption of DBM.

• OSTI ID: 6522249
• Journal Information: Clinical Orthopaedics and Related Research; (USA), Journal Name: Clinical Orthopaedics and Related Research; (USA) Vol. 257; ISSN CORTB; ISSN 0009-921X
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH METALS
AMINES
AMINO ACIDS
ANIMALS
ANTIPYRETICS
AZOLES
BODY
CALCIUM
CARBOXYLIC ACIDS
CELL DIFFERENTIATION
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
ELEMENTS
ENZYME INHIBITORS
GRAFTS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
INHIBITION
ISOTOPE APPLICATIONS
MAMMALS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PROLINE
PYRROLES
PYRROLIDINES
RATS
RODENTS
SKELETON
TRACER TECHNIQUES
TRANSPLANTS
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES