In vitro radiosensitivity of fibroblasts derived from patients with retinoblastoma and abnormalities of chromosome 13
Journal Article
·
· Retina; (United States)
In vitro x-ray survival experiments were performed on fibroblast strains derived from nine patients with sporatic unilateral retinoblastoma and 26 patients with hereditary retinoblastoma. Fibroblasts derived from patients with hereditary retinoblastoma were significantly more radiosensitive than those derived from patients with sporatic retinoblastoma. The authors hypothesize that the increased in vitro radiosensitivity observed in some hereditary retinoblastoma cell strains is a reflection of an, as yet, uncharacterized defect in DNA repair or post-irradiation DNA replication. X-ray sensitivity was also measured in 19 fibroblast strains derived from patients bearing deletions, trisomies, inversions, or translocations of all or part of chromosome 13. These results are compared with data from individuals trisomic for three other autosomes. The results suggest an association between abnormalities of chromosome 13 and the cytotoxic effects of x-irradiation.
- Research Organization:
- Joint Center for Radiation Therapy, Boston, Massachusetts
- OSTI ID:
- 5428718
- Journal Information:
- Retina; (United States), Journal Name: Retina; (United States) Vol. 3:2; ISSN RETID
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
BODY AREAS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DISEASES
DNA
ELECTROMAGNETIC RADIATION
EYES
FACE
FIBROBLASTS
HEAD
IONIZING RADIATIONS
MUTATIONS
NEOPLASMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RECOVERY
REPAIR
RETINA
SENSE ORGANS
SOMATIC CELLS
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
BODY AREAS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DISEASES
DNA
ELECTROMAGNETIC RADIATION
EYES
FACE
FIBROBLASTS
HEAD
IONIZING RADIATIONS
MUTATIONS
NEOPLASMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RECOVERY
REPAIR
RETINA
SENSE ORGANS
SOMATIC CELLS
X RADIATION