In vitro investigation of x-ray sensitivity in fibroblasts from patients with retinoblastoma

Journal Article · Fri Jul 01 04:00:00 EDT 1983 · Invest. Ophthalmol. Visual Sci.; (United States)

OSTI ID:5126726

Weichselbaum, R; Albert, D M; Cassady, J R; Little, J B

In vitro x-ray survival experiments were performed on fibroblast strains derived from nine patients with sporadic unilateral retinoblastoma, 26 patients with hereditary retinoblastoma, and six normal controls. The x-ray sensitivity of the strains derived from the sporadic retinoblastoma patients and normal controls did not significantly differ from one another. The fibroblast strains derived from patients with hereditary retinoblastoma were significantly more radiosensitive to killing by x-rays as measured by clonogenic survival than either the sporadic strains or the strains derived from normal controls. We hypothesize that the increased in vitro radiosensitivity observed in some hereditary retinoblastoma strains is a reflection of an as yet uncharacterized defect in DNA or DNA replication postirradiation.

• Research Organization: Harvard Medical School, Boston, MA
• OSTI ID: 5126726
• Journal Information: Invest. Ophthalmol. Visual Sci.; (United States), Journal Name: Invest. Ophthalmol. Visual Sci.; (United States) Vol. 24:7; ISSN IOVSD
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL KILLING
CONNECTIVE TISSUE CELLS
DISEASES
DNA
DNA REPLICATION
ELECTROMAGNETIC RADIATION
FIBROBLASTS
IONIZING RADIATIONS
NEOPLASMS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PATIENTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY
RECOVERY
REPAIR
SOMATIC CELLS
SURVIVAL CURVES
X RADIATION