C-11 dimethyloxazolidinedione (DMO): biodistribution, radiation absorbed dose, and potential for PET measurement of regional brain pH: concise communication

Journal Article · Thu Sep 01 04:00:00 EDT 1983 · J. Nucl. Med.; (United States)

OSTI ID:5428652

Kearfott, K J; Junck, L; Rottenberg, D A

An improved radiochemical synthesis for C-11 dimethyloxazolidinedione (C-11 DMO) makes this agent attractive for the measurement of regional brain tissue pH (rpH) using positron emission tomography (PET). Toward this end, biodistribution data for C-14 DMO in rats at various times after an intravenous bolus injection are reported, together with estimates of radiation absorbed dose for C-11 DMO in man. An error analysis of C-11 DMO PET measurement of rpH indicates that rpH can be determined to within +/- 0.1 pH unit for pH greater than 6.5 with a 20-mCi injected bolus of C-11 DMO, a 30- 45-min equilibration time, and a 15-min PET imaging period.

• Research Organization: Dept. of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY
• OSTI ID: 5428652
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 24:9; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTICONVULSANTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBON 11
CARBON 14
CARBON 14 COMPOUNDS
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHEMISTRY
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DOSES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
PH VALUE
POSITRON COMPUTED TOMOGRAPHY
RADIATION DOSES
RADIOCHEMISTRY
RADIOISOTOPES
RATS
RODENTS
TOMOGRAPHY
TRACER TECHNIQUES
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES