Myelin imaging with C-11 labeled diphenylmethanol and positron emission tomography

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6709214

Herscovitch, P; Dischino, D D; Kilbourn, M R; Welch, M J; Raichle, M E

The authors have recently studied several C-11-labeled radiopharmaceuticals for their suitability as myelin imaging agents with positron emission tomography (PET). C-11 diphenylmethanol (DPM) was selected on the basis of its in vivo metabolic stability and high extraction and lipophilicity. PET studies were performed in three normal subjects and in one patient with multiple sclerosis (MS). Myelin distribution was imaged following the bolus intravenous administration of 25-30 mCi of C-11 DPM. Sequential scans were obtained after radiotracer administration to measure the DPM distribution as a function of time. In addition, regional cerebral blood flow was measured after the bolus intravenous injection of 0-15 water. A tomographic slice through the centrum semiovale was used to obtain regional data for gray matter (GM) and white matter (WM).

• Research Organization: Washington Univ. School of Medicine, St. Louis, MO
• OSTI ID: 6709214
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ALCOHOLS
BENZHYDROL
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BLOOD FLOW
BODY
BRAIN
CARBON 11
CARBON ISOTOPES
CELL CONSTITUENTS
CELL MEMBRANES
CENTRAL NERVOUS SYSTEM
CEREBRUM
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DISTRIBUTION
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
IN VIVO
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
MEMBRANES
METABOLIC ACTIVATION
METABOLISM
MINUTES LIVING RADIOISOTOPES
MYELIN
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXYGEN 15
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
RADIONUCLIDE ADMINISTRATION
RADIOPHARMACEUTICALS
TIME DEPENDENCE
TISSUE DISTRIBUTION
TOMOGRAPHY
TRACER TECHNIQUES
USES
WATER