In vivo measurement of brain tumor pH using /sup 11/CDMO and positron emission tomography
Journal Article
·
· Ann. Neurol.; (United States)
In vivo measurements of regional brain tissue/tumor pH (rpH) have been accomplished in 9 patients with primary or metastatic brain tumors using (/sup 11/C)dimethyloxazolidinedione ((/sup 11/C)DMO) and positron emission tomography. Tumor rpH values ranged from 6.88 to 7.26, whereas gray matter and white matter rpH values ranged from 6.74 to 7.09 and from 6. 77 to 7.03, respectively. The results, which are consistent with reported (/sup 14/C)DMO autoradiographic measurements of brain and tumor pH, suggest that the pH microenvironment of brain tumors is not more ''acidic'' than that of normal gray or white matter.
- Research Organization:
- Memorial Sloan-Kettering Cancer Center, New York, NY
- OSTI ID:
- 5679773
- Journal Information:
- Ann. Neurol.; (United States), Journal Name: Ann. Neurol.; (United States) Vol. 17:1; ISSN ANNED
- Country of Publication:
- United States
- Language:
- English
Similar Records
C-11 dimethyloxazolidinedione (DMO): biodistribution, radiation absorbed dose, and potential for PET measurement of regional brain pH: concise communication
C-11 dimethyloxazolidinedione (DMO): biodistribution, radiation absorbed dose, and potential for PET measurement of regional brain pH: concise communication
Studies on regional cerebral pH in patients with cerebral tumors using continuous inhalation of /sup 11/CO/sub 2/ and positron emission tomography
Journal Article
·
Thu Sep 01 00:00:00 EDT 1983
· J. Nucl. Med.; (United States)
·
OSTI ID:5640939
C-11 dimethyloxazolidinedione (DMO): biodistribution, radiation absorbed dose, and potential for PET measurement of regional brain pH: concise communication
Journal Article
·
Thu Sep 01 00:00:00 EDT 1983
· J. Nucl. Med.; (United States)
·
OSTI ID:5428652
Studies on regional cerebral pH in patients with cerebral tumors using continuous inhalation of /sup 11/CO/sub 2/ and positron emission tomography
Journal Article
·
Wed Oct 01 00:00:00 EDT 1986
· J. Cereb. Blood Flow Metab.; (United States)
·
OSTI ID:7024134
Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBON 11
CARBON 14 COMPOUNDS
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
IN VIVO
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
METASTASES
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ORGANS
PATIENTS
PH VALUE
RADIOISOTOPES
TOMOGRAPHY
TRACER TECHNIQUES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBON 11
CARBON 14 COMPOUNDS
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
IN VIVO
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
METASTASES
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ORGANS
PATIENTS
PH VALUE
RADIOISOTOPES
TOMOGRAPHY
TRACER TECHNIQUES