Response of colony-forming units-spleen to heavy charged particles

Journal Article · Sat Oct 01 04:00:00 EDT 1983 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576177· OSTI ID:5427677

Ainsworth, E J; Kelly, L S; Mahlmann, L J; Thomas, R H; Howard, J; Alpen, E L

Survival of colony-forming units-spleen (CFU-S) was measured after single doses of photons or heavy charged particles from the BEVALAC. The purposes were to define the radiosensitivity to heavy ions used medically and to evaluate relationships between relative biological effectiveness (RBE) and dose-averaged linear energy transfer (LET/sub Infinity/). In in vitro irradiation experiments, CFU-S suspensions were exposed to 220 kVp X rays or to /sup 20/Ne (372 MeV/..mu..m) or /sup 40/Ar (447 MeV/..mu..m) particles in the plateau portion of the Bragg curve. In in vivo irradiation experiments, donor mice from which CFU-S were harvested were exposed to /sup 12/C (400 MeV/..mu..m), /sup 20/Ne (400 or 670 MeV/..mu..m), or /sup 40/Ar (570 MeV/..mu..m) particles in Bragg peaks spread to 4 or 10 cm by spiral ridge filters. Based on RBE at 10 survival, the maximum RBE of 2.1 was observed for /sup 40/Ar particle characterized by an LET/sub Infinity/ of approx. 100 keV/..mu..m. The responses of CFU-S are compared with responses of other model sytems to heavy charged particles and with the reported sensitivity of CFU-S to neutrons of various energies. Low energy /sup 12/C and /sup 20/Ne particles have RBEs in the range of values reported for 14.7 MeV neutrons.

• Research Organization: Lawrence Berkeley Lab., CA
• DOE Contract Number: AC03-76SF00098
• OSTI ID: 5427677
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 96:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

550300 -- Cytology
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARGON 40 BEAMS
BEAMS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBON 12 BEAMS
CFU
COBALT 60
COBALT ISOTOPES
COLONY FORMATION
DATA
ELECTROMAGNETIC RADIATION
ENERGY TRANSFER
EXPERIMENTAL DATA
GAMMA RADIATION
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ION BEAMS
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LET
MAMMALS
MICE
MINUTES LIVING RADIOISOTOPES
NEON 20 BEAMS
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RBE
RODENTS
SPLEEN
SPLEEN COLONY FORMATION
SURVIVAL CURVES
VERTEBRATES
X RADIATION
YEARS LIVING RADIOISOTOPES