Drastic G/sub 2/ arrest in mammalian cells after irradiation with heavy-ion beams. [/sup 40/Ar, /sup 12/C, /sup 20/Ne beams; V79 cultured cells]
Journal Article
·
· Radiat. Res.; (United States)
Unsynchronized exponentially growing V79 monolayer cultures were exposed to high-energy accelerated heavy-ion beams (/sup 12/C, /sup 20/Ne, /sup 40/Ar) at various positions in their unmodified Bragg ionization curves. High-LET particle beams proved to be much more effective in causing a G/sub 2/ + M block, measured by the method of flow microfluorometry, than low-LET radiation. The number of cells arrested in G/sub 2/ + M increased linearly with dose up to at least 75% of the maximum effect. In this domain, the RBE values were LET-dependent with a maximum (RBE/sub 50/ = 8.3) at about 100 keV/..mu..m. In contrast to ..gamma.. and x rays, heavy ions with high LET did not affect cell traverse through the G/sub 1/ and S phase. Though the RBE values for G/sub 2/ + M block are much higher than the RBEs for survival, there was a linear relationship between accumulation of cells in G/sub 2/ + M and cell killing.
- Research Organization:
- Univ. of California, Berkeley
- OSTI ID:
- 5487668
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 19:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ARGON 40 BEAMS
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARBON 12 BEAMS
CELL CULTURES
CELL CYCLE
CELL KILLING
COMPARATIVE EVALUATIONS
CORRELATIONS
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ENERGY DEPENDENCE
ENERGY TRANSFER
EXPERIMENTAL DATA
GRAPHS
HAMSTERS
IN VITRO
INFORMATION
ION BEAMS
IONIZING RADIATIONS
IRRADIATION
LET
MAMMALS
MITOTIC DELAY
NEON 20 BEAMS
NUMERICAL DATA
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RBE
RODENTS
SURVIVAL CURVES
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ARGON 40 BEAMS
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARBON 12 BEAMS
CELL CULTURES
CELL CYCLE
CELL KILLING
COMPARATIVE EVALUATIONS
CORRELATIONS
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ENERGY DEPENDENCE
ENERGY TRANSFER
EXPERIMENTAL DATA
GRAPHS
HAMSTERS
IN VITRO
INFORMATION
ION BEAMS
IONIZING RADIATIONS
IRRADIATION
LET
MAMMALS
MITOTIC DELAY
NEON 20 BEAMS
NUMERICAL DATA
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RBE
RODENTS
SURVIVAL CURVES
VERTEBRATES
X RADIATION