High pressure liquid chromatographic gradient mixer
Patent
·
OSTI ID:5420588
A gradient mixer which effects the continuous mixing of any two miscible solvents without excessive decay or dispersion of the resultant isocratic effluent or of a linear or exponential gradient. The two solvents are fed under low or high pressure by means of two high performance liquid chromatographic pumps. The mixer comprises a series of ultra-low dead volume stainless steel tubes and low dead volume chambers. The two solvent streams impinge head-on at high fluxes. This initial nonhomogeneous mixture is then passed through a chamber packed with spirally-wound wires which cause turbulent mixing thereby homogenizing the mixture with minimum ''band-broadening''.
- Assignee:
- The United States of America as represented by the United States Department of Energy
- Patent Number(s):
- US 4506987
- Application Number:
- TRN: 85-019281
- OSTI ID:
- 5420588
- Resource Relation:
- Patent File Date: Filed date 8 Sep 1982; Other Information: PAT-APPL-415946
- Country of Publication:
- United States
- Language:
- English
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