High-pressure liquid chromatographic gradient mixer
Patent
·
OSTI ID:5708006
A gradient mixer effects the continuous mixing of any two miscible solvents without excessive decay or dispersion of the resultant isocratic effluent or of a linear or exponential gradient. The two solvents are fed under low or high pressure by means of two high performance liquid chromatographic pumps. The mixer comprises a series of ultra-low dead volume stainless steel tubes and low dead volume chambers. The two solvent streams impinge head-on at high fluxes. This initial nonhomogeneous mixture is then passed through a chamber packed with spirally-wound wires which cause turbulent mixing thereby homogenizing the mixture with minimum band-broadening.
- DOE Contract Number:
- W-7405-ENG-48
- Assignee:
- EDB-83-178040; ERA-08-054486
- Patent Number(s):
- None
- Application Number:
- ON: DE83018103
- OSTI ID:
- 5708006
- Country of Publication:
- United States
- Language:
- English
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