High pressure liquid chromatographic gradient mixer

Patent · Tue Jan 01 00:00:00 EST 1985

OSTI ID:865383

Daughton, Christian G ^[1]; Sakaji, Richard H ^[2]

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1. San Pablo, CA
2. El Cerrito, CA

A gradient mixer which effects the continuous mixing of any two miscible solvents without excessive decay or dispersion of the resultant isocratic effluent or of a linear or exponential gradient. The two solvents are fed under low or high pressure by means of two high performance liquid chromatographic pumps. The mixer comprises a series of ultra-low dead volume stainless steel tubes and low dead volume chambers. The two solvent streams impinge head-on at high fluxes. This initial nonhomogeneous mixture is then passed through a chamber packed with spirally-wound wires which cause turbulent mixing thereby homogenizing the mixture with minimum "band-broadening".

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
• DOE Contract Number: W-7405-ENG-48
• Assignee: United States of America as represented by United States (Washington, DC)
• Patent Number(s): US 4506987
• OSTI ID: 865383
• Country of Publication: United States
• Language: English

Related Subjects

pressure
liquid
chromatographic
gradient
mixer
effects
continuous
mixing
miscible
solvents
excessive
decay
dispersion
resultant
isocratic
effluent
linear
exponential
fed
means
performance
pumps
comprises
series
ultra-low
dead
volume
stainless
steel
tubes
chambers
solvent
streams
impinge
head-on
fluxes
initial
nonhomogeneous
mixture
passed
chamber
packed
spirally-wound
wires
turbulent
homogenizing
minimum
band-broadening
performance liquid
liquid chromatograph
dead volume
stainless steel
homogeneous mixture
liquid chromatographic
pressure liquid
turbulent mixing
solvent stream
volume chambers
gradient mixer
miscible solvents
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