Effects of grisorixin on the distribution of thallium-201 and on the oxidative metabolism in cultured myocardial cells

Journal Article · Sat Jun 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5414946

Maublant, J C; Moins, N; Gachon, P; Ross, M R; Davidson, W D; Mena, I

Previous experiments in the dog and guinea-pig have shown that grisorixin, a monocarboxylic ionophore, can significantly increase the coronary blood flow and the myocardial uptake of /sup 201/Tl, as well as have a stimulant effect on the heart. In this study, cultures of myocardial cells were used in order to isolate the cells from the vascular and extracardiac influences so that any ionophorous effect on /sup 201/Tl could be evidence. The effects of grisorixin on the oxidative metabolism were simultaneously studied. The activity of the /sup 14/CO/sub 2/ produced by oxidation of (/sup 14/C)glucose and (/sup 14/C)octanoate added to the medium of culture and the intra/extracellular ratio of /sup 201/Tl concentrations (Tl i/e) were measured. The conclusion is that grisorixin decreases both the intracellular concentration of /sup 201/Tl and the fatty-acids oxidation in cultured myocardial cells. The beneficial effects previously observed in vivo were probably the consequence of the strong coronary dilatation and of an indirect stimulation.

• Research Organization: Harbor-UCLA Medical Center, Torrance
• OSTI ID: 5414946
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:6; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CARBOHYDRATES
CARBON 14 COMPOUNDS
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CELL CULTURES
CHALCOGENIDES
CHEMICAL REACTIONS
DAYS LIVING RADIOISOTOPES
DECOMPOSITION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GLUCOSE
GLYCOLYSIS
HEART
HEAVY NUCLEI
HEXOSES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
METABOLISM
MONOCARBOXYLIC ACIDS
MONOSACCHARIDES
MUSCLES
MYOCARDIUM
NUCLEI
OCTANOIC ACID
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RODENTS
SACCHARIDES
SECONDS LIVING RADIOISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
UPTAKE
VERTEBRATES