Myocardial imaging in dogs treated with grisorixin: relationship between /sup 201/Tl uptake and coronary blood flow

Journal Article · Thu Apr 01 04:00:00 EST 1982 · J. Nucl. Med.; (United States)

OSTI ID:6780860

Moins, N; Gachon, P; Maublant, J

/sup 201/Tl myocardial imaging was performed in dogs after pretreatment with grisorixin, which appeared to increase the myocardial uptake of /sup 201/Tl. This effect of grisorixin was found to be dose dependent, with an optimal dose of 60 microgram/kg. The myocardial-to-background ratio, which was 1.92 in the control dogs, rose to 4.45. The increase in the absolute myocardial uptake was demonstrated in guinea pigs that received /sup 201/Tl after similar pretreatment with grisorixin. In the animals treated with 500 microgram/kg, the uptake of /sup 201/Tl by the heart was 35% over the control value. With 60 microgram/kg grisorixin, the coronary blood flow increased from 40 to 176 ml/min 5 min after the injection. This dose, optimal for imaging, induced the maximum vasodilator effect with only a very slight concomitant increase in the left-ventricular pressure and myocardial contractility. Above 60 microgram/kg, grisorixin appeared to be a potent inotropic agent, whereas below this dose it showed only coronary vasodilator properties. Some evidence for an ionophore effect of this compound was found in dogs pretreated with 60 microgram/kg. In these the radionuclide was injected when the coronary vasodilatation had become insignificant, but a significant improvement of the M/B ratio was still evident.

• Research Organization: U. 195 INSERM, University of Clermont-Ferrand, France
• OSTI ID: 6780860
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:4; ISSN JNMEA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ARTERIES
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BLOOD CIRCULATION
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
CORONARIES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DOGS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GUINEA PIGS
HEART
HEAVY NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOSENSITIVITY EFFECTS
RODENTS
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
SYMPATHOMIMETICS
THALLIUM 201
THALLIUM ISOTOPES
UPTAKE
USES
VASODILATION
VERTEBRATES