Modification by cysteamine of ultrasound lethality to Chinese hamster V-79 cells
Journal Article
·
· Radiat. Res.; (United States)
- Univ. of Rochester, NY
Exposure of Chinese hamster V-79 cells to 1.1-MHz continuous wave (C-W) ultrasound at intensities of 10, 20, and 30 W/cm/sup 2/ resulted in cell lysis and the loss of reproductive integrity (i.e., a decrease in plating efficiency) in the remaining intact cells. Sonication in the presence of 8 mM cysteamine, a free-radical scavenger, did not alter the amount of cell lysis, but did result in a smaller decrease in plating efficiency at 20 and 30 W/cm/sup 2/. Hence, while free radicals do not appear responsible for ultrasonically induced cell lysis, free radicals do appear to be at least partially responsible for loss of reproductive integrity in the remaining intact cells.
- OSTI ID:
- 5413327
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Journal Issue: 3 Vol. 80:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Sat Dec 31 23:00:00 EST 1977
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·
OSTI ID:6110434
Related Subjects
550300 -- Cytology
560400* -- Other Environmental Pollutant Effects
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BIOLOGICAL EFFECTS
CELL CULTURES
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
EXPERIMENTAL DATA
FERTILITY
HAMSTERS
INFORMATION
ISOLATED VALUES
LYSIS
MAMMALS
MEA
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADICALS
RADIOPROTECTIVE SUBSTANCES
REPRODUCTION
RESPONSE MODIFYING FACTORS
RODENTS
SOUND WAVES
SURVIVAL CURVES
THIOLS
TOLERANCE
ULTRASONIC WAVES
VERTEBRATES
560400* -- Other Environmental Pollutant Effects
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BIOLOGICAL EFFECTS
CELL CULTURES
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
EXPERIMENTAL DATA
FERTILITY
HAMSTERS
INFORMATION
ISOLATED VALUES
LYSIS
MAMMALS
MEA
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADICALS
RADIOPROTECTIVE SUBSTANCES
REPRODUCTION
RESPONSE MODIFYING FACTORS
RODENTS
SOUND WAVES
SURVIVAL CURVES
THIOLS
TOLERANCE
ULTRASONIC WAVES
VERTEBRATES