Kinetics of (/sup 14/C-5) 8-methoxypsoralen uptake by UVA irradiated and non-irradiated rabbit eye tissues
Journal Article
·
· Res. Commun. Chem. Pathol. Pharmacol.; (United States)
OSTI ID:5405231
Total 8-methoxypsoralen (8-MOP) in intact and UVA irradiated rabbit eye tissues and its unaltered fraction in aqueous and eye lenses were determined over the 24 hours after i.v. injection of (/sup 14/C-5) and carrier 8-MOP at the concentration of 50 microCi and 5 mg/kg. No 8-MOP was detected at the end of 24 hours in intact and irradiated aqueous, vitreous and retina in contrast to one hour when the respective levels were congruent to 220, greater than 0 and congruent to 160 ng/g. Eye-plasma drug concentration ratios were less than 0.5 initially, but increased thereafter. While the average lens 8-MOP levels of congruent to 140 ng/g remained unchanged for 24 hours, no unaltered drug was detected beyond eight hours. Measurable amounts of label at the end of 24 hours also persisted in the cornea, iris, sclera and conjunctiva.
- OSTI ID:
- 5405231
- Journal Information:
- Res. Commun. Chem. Pathol. Pharmacol.; (United States), Journal Name: Res. Commun. Chem. Pathol. Pharmacol.; (United States) Vol. 32:2; ISSN RCOCB
- Country of Publication:
- United States
- Language:
- English
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·
OSTI ID:5018870
Related Subjects
550201 -- Biochemistry-- Tracer Techniques
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTICOAGULANTS
BODY
BODY AREAS
CARBON 14 COMPOUNDS
CHEMICAL ANALYSIS
COMPARATIVE EVALUATIONS
COUMARINS
DRUGS
ELECTROMAGNETIC RADIATION
EYES
FACE
HEAD
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
LABELLED COMPOUNDS
MAMMALS
MEASURING METHODS
METABOLISM
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PSORALEN
QUANTITATIVE CHEMICAL ANALYSIS
QUANTITY RATIO
RABBITS
RADIATIONS
RADIONUCLIDE KINETICS
SENSE ORGANS
TIME DEPENDENCE
ULTRAVIOLET RADIATION
UPTAKE
VERTEBRATES
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTICOAGULANTS
BODY
BODY AREAS
CARBON 14 COMPOUNDS
CHEMICAL ANALYSIS
COMPARATIVE EVALUATIONS
COUMARINS
DRUGS
ELECTROMAGNETIC RADIATION
EYES
FACE
HEAD
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
LABELLED COMPOUNDS
MAMMALS
MEASURING METHODS
METABOLISM
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PSORALEN
QUANTITATIVE CHEMICAL ANALYSIS
QUANTITY RATIO
RABBITS
RADIATIONS
RADIONUCLIDE KINETICS
SENSE ORGANS
TIME DEPENDENCE
ULTRAVIOLET RADIATION
UPTAKE
VERTEBRATES