Effect of hypoxia on the incorporation of (2-3H) glycerol and (1-14C(-palmitate into lipids of various brain regions
The lipid metabolism in guinea pig brain after intermittent hypoxia, prolonged for 80 hrs, was markedly impaired. The in vivo incorporation of (2-3H) glycerol and (1-14C) palmitate into lipids of microsomes, mitochondria, myelin, and synaptosomes, purified form cerebral hemispheres, was significantly lower in the hypoxic animals than in the controls. The same effect was observed on the incorporation of labeled precursors into lipids of mitochondria purified from cerebellum and brainstem. In particular, the labeling of th major phospholipids present - ie, phosphatidylcholine (PC) and phosphatidylethanolamine (PE) - in the mitochondria of the three brain regions examined decreased after hypoxic treatment.
- Research Organization:
- Institute of Biochemistry, University of Catania, Italy
- OSTI ID:
- 5394214
- Journal Information:
- J. Neurosci. Res.; (United States), Journal Name: J. Neurosci. Res.; (United States) Vol. 6:3; ISSN JNRED
- Country of Publication:
- United States
- Language:
- English
Similar Records
Physical properties, lipid composition and enzyme activities of hepatic subcellular membranes from chick embryo after ethanol treatment
Adrenocorticotropin and adenosine 3',5'-monophosphate stimulate de novo synthesis of adrenal phosphatidic acid by a cycloheximide-sensitive, CA++-dependent mechanism
Related Subjects
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALCOHOLS
ANIMALS
ANOXIA
BODY
BRAIN
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM
ESTERS
GLYCEROL
GUINEA PIGS
HEXADECANOIC ACID
HYDROXY COMPOUNDS
IN VIVO
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIPIDS
LIPOPROTEINS
MAMMALS
METABOLISM
MICROSOMES
MITOCHONDRIA
MONOCARBOXYLIC ACIDS
MYELIN
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANOIDS
ORGANS
PATHOLOGY
PHOSPHOLIPIDS
PROTEINS
RODENTS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES