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Effect of CDP-choline on the biosynthesis of phospholipids in brain regions during hypoxic treatment

Journal Article · · J. Neurosci. Res.; (United States)
; ; ; ;

Acute administration of CDP-choline (i.p. 100 mg/Kg b.w.), 10 min before the intraventricular injection of labeled precursors, (2-3H) glycerol and (1-14C)-palmitate, was able to correct the impairment caused by hypoxic treatment of lipid metabolism in some brain regions, ie, cerebral hemispheres, cerebellum, and brainstem. After CDP-choline treatment, an increase of the specific radioactivity of total lipids and of phospholipids was observed in mitochondria purified from the three above-mentioned brain regions of the hypoxic animals, while no effect on the other subcellular fractions was found. CDP-Choline had a stimulating effect particularly on the incorporation of both precursors into mitochondrial PC, PE, and polyglycerophosphatides isolated form the three brain regions examined. The results obtained show that the action of CDP-choline in restoring lipid metabolism was more pronounced in brain mitochondria, which, among subcellular fractions, were the most affected by the hypoxic treatment.

Research Organization:
Institute of biochemistry, University of Catania, Italy
OSTI ID:
5394213
Journal Information:
J. Neurosci. Res.; (United States), Journal Name: J. Neurosci. Res.; (United States) Vol. 6:3; ISSN JNRED
Country of Publication:
United States
Language:
English

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Related Subjects

550201* -- Biochemistry-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALCOHOLS
AMINES
AMMONIUM COMPOUNDS
ANOXIA
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
BRAIN
CARBON 14 COMPOUNDS
CARBOXYLIC ACID ESTERS
CENTRAL NERVOUS SYSTEM
CHOLINE
DRUGS
ESTERS
GLYCEROL
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
LIPIDS
LIPOTROPIC FACTORS
METABOLISM
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHOLIPIDS
PRECURSOR
QUATERNARY COMPOUNDS
REACTION KINETICS
SYNTHESIS
TRACER TECHNIQUES
TRITIUM COMPOUNDS