In vitro microwave effects on human neutrophil precursor cells (CFU-C)
Journal Article
·
· Bioelectromagnetics (N.Y.); (United States)
Human marrow cells were irradiated with 2450-MHz CW microwaves in a fluid-filled waveguide irradiation system. Cell exposure was conducted by placing a marrow cell suspension in 20-microliter glass microcapillary tubes were positioned in the exposure chamber, and irradiated at power densities from 31 to 1,000 mW/cm2 (with corresponding specific absorption rates of 62 to 2,000 mW/g) for 15 minutes. The temperature of the sample was maintained at a fixed point. Sham-irradiated (SI) and microwave-irradiated (MWI) cells were cultured in a methylcellulose culture system for neutrophil colony proliferation. There was no reduction in neutrophil colony number on days 6-7 or 12-14 in cells exposed at 31 or 62 mW/cm2, but as the power density was increased to 1,000 mW/cm2, there was a reduction in colony number of MWI cells compared with SI cells. The microwave interaction with the human neutrophil colony-forming cells was apparently not related to temperature rise, or to the state of cells cycle, and was irreversible.
- Research Organization:
- Wayne State University, Department of Pediatrics, Detroit
- OSTI ID:
- 5386457
- Journal Information:
- Bioelectromagnetics (N.Y.); (United States), Journal Name: Bioelectromagnetics (N.Y.); (United States) Vol. 2:3; ISSN BLCTD
- Country of Publication:
- United States
- Language:
- English
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Technical Report
·
Sun Jun 01 00:00:00 EDT 1975
·
OSTI ID:4062525
Related Subjects
550300 -- Cytology
560400* -- Other Environmental Pollutant Effects
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
BONE MARROW CELLS
CELL CULTURES
CELL CYCLE
CELL PROLIFERATION
COLONY FORMATION
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
IN VITRO
LEUKOCYTES
MATERIALS
MICROWAVE RADIATION
NEUTROPHILS
POWER DENSITY
PRECURSOR
RADIATIONS
RADIOSENSITIVITY
SOMATIC CELLS
560400* -- Other Environmental Pollutant Effects
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
BONE MARROW CELLS
CELL CULTURES
CELL CYCLE
CELL PROLIFERATION
COLONY FORMATION
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
IN VITRO
LEUKOCYTES
MATERIALS
MICROWAVE RADIATION
NEUTROPHILS
POWER DENSITY
PRECURSOR
RADIATIONS
RADIOSENSITIVITY
SOMATIC CELLS