Hypertension in rats deficient in copper
Male weanling rats were matched into two groups of equal mean weight (48 g), were fed a diet low in copper and zinc and were supplemented with a drinking solution with 10..mu..gZn and 2/sup +/gCu per ml until they grew to approximately 300 g. Systolic blood pressure (mmHg) was measured without anesthesia with an Electro-Sphygmomanometer and pneumatic pulse transducer; no significant difference between groups was found (0 > 0.05). Then copper was omitted from the solution of the group with lower blood pressure in each of two experiments. Plasma cholesterol (mg/dl) was measured by fluorometry and blood pressure was measured again 53 to 86 days later; mean (SE), n = 14, 15. Hypercholesterolemia verified deficiency. Hypotension in copper deficient rats in experiments of others probably was the result of cardiac defects induced in weanling animals. Hypertension joins hypercholesterolemia, hyperuricemia, glucose intolerance and abnormal electrocardiograms as a stigma of copper deficiency. Copper deficiency is the only nutritional insult that induces all of these characteristics useful in predicting risk of ischemic heart disease.
- Research Organization:
- Dept. of Agriculture, Grand Forks, ND
- OSTI ID:
- 5382115
- Report Number(s):
- CONF-8604222-
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effects of cadmium ingestion in rats with opposite genetic predisposition to hypertension
The effect dietary Cu intake on the development of hypertension in the Dahl-S rat
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
COPPER
BIOLOGICAL EFFECTS
NUTRITIONAL DEFICIENCY
ISCHEMIA
RISK ASSESSMENT
BIOLOGICAL MODELS
BLOOD PRESSURE
CHOLESTEROL
HYPERTENSION
RATS
ANIMALS
CARDIOVASCULAR DISEASES
DISEASES
ELEMENTS
HYDROXY COMPOUNDS
MAMMALS
METALS
ORGANIC COMPOUNDS
RODENTS
STEROIDS
STEROLS
SYMPTOMS
TRANSITION ELEMENTS
VASCULAR DISEASES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550900 - Pathology