Lead and selenium effects on glutathione metabolism in the chick
Conference
·
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
OSTI ID:5381912
The effects of lead (Pb) and selenium (Se) on certain aspects of glutathione (GSH) turnover in the chick were examined in a series of 2 x 2 factorial experiments. Organ GSH, total non-protein sulfhydryl (NPSH), and GSH-related amino acid concentrations were measured in chicks fed a glucose-soybean meal diet supplemented with 0 or 2000 ppm Pb as Pb acetate x /sup 3/H/sub 2/O and 0 or 20 ppm Se as Na/sub 2/SeO/sub 3/ from 1 to 21 days of age. Significant changes in the concentrations of GSH, NPSH, glutamate (GLU), glucine (GLY), methionine (MET), and cystine (CYS) in liver, kidneys, and plasma due to Pb and Se administration are described. Plasma CYS and MET tended to be lowered, though not always significantly (NS), by both Pb and Se. Liver MET was decreased (NS) by Se, but increased (P < 0.05) by Pb. Liver NPSH and GSH were increased (NS) by Pb. These data suggest an enhancement of GSH turnover by toxic levels of both Pb and Se, possibly by different mechanisms. Further research on mechanisms of the Pb and Se effects are planned.
- Research Organization:
- Univ. of Florida, Gainesville
- OSTI ID:
- 5381912
- Report Number(s):
- CONF-8604222-
- Conference Information:
- Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIRDS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
CHICKENS
DIGESTIVE SYSTEM
DRUGS
ELEMENTS
FOWL
GLANDS
GLUTATHIONE
ISOTOPE APPLICATIONS
KIDNEYS
LABELLED COMPOUNDS
LEAD
LIVER
MATERIALS
METABOLISM
METALS
ORGANIC COMPOUNDS
ORGANS
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
SELENIUM
SEMIMETALS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIRDS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
CHICKENS
DIGESTIVE SYSTEM
DRUGS
ELEMENTS
FOWL
GLANDS
GLUTATHIONE
ISOTOPE APPLICATIONS
KIDNEYS
LABELLED COMPOUNDS
LEAD
LIVER
MATERIALS
METABOLISM
METALS
ORGANIC COMPOUNDS
ORGANS
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
SELENIUM
SEMIMETALS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES