Smoke aldehyde component influences pulmonary edema

Journal Article · Sat Feb 01 04:00:00 EST 1992 · Journal of Applied Physiology (1985); (United States)

OSTI ID:5375424

Hales, C A; Musto, S W; Janssens, S; Jung, W; Quinn, D A; Witten, M ^[1]

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1. Department of Medicine (Pulmonary/Critical Care Unit), Massachusetts General Hospital, Boston (United States)

The pulmonary edema of smoke inhalation is caused by the toxins of smoke and not the heat. We investigated the potential of smoke consisting of carbon in combination with either acrolein or formaldehyde (both common components of smoke) to cause pulmonary edema in anesthetized sheep. Seven animals received acrolein smoke, seven animals received a low-dose formaldehyde smoke, and five animals received a high-dose formaldehyde smoke. Pulmonary arterial pressure, pulmonary capillary wedge pressure, and cardiac output were not affected by smoke in any group. Peak airway pressure increased after acrolein (14 +/- 1 to 21 +/- 2 mmHg; P less than 0.05) and after low- and high-dose formaldehyde (14 +/- 1 to 21 +/- 1 and 20 +/- 1 mmHg, respectively; both P less than 0.05). The partial pressure of O2 in arterial blood fell sharply after acrolein (219 +/- 29 to 86 +/- 9 (SE) Torr; P less than 0.05) but not after formaldehyde. Only acrolein resulted in a rise in lung lymph flow (6.5 +/- 2.2 to 17.9 +/- 2.6 ml/h; P less than 0.05). Lung lymph-to-plasma protein ratio was unchanged for all three groups, but clearance of lymph protein was increased after acrolein. After acrolein, the blood-free extravascular lung water-to-lung dry weight ratio was elevated (P less than 0.05) compared with both low- and high-dose formaldehyde groups (4.8 +/- 0.4 to 3.3 +/- 0.2 and 3.6 +/- 0.2, respectively). Lymph clearance (ng/h) of thromboxane B2, leukotriene B4, and the sulfidopeptide leukotrienes was elevated after acrolein but not formaldehyde.(ABSTRACT TRUNCATED AT 250 WORDS)

• OSTI ID: 5375424
• Journal Information: Journal of Applied Physiology (1985); (United States), Journal Name: Journal of Applied Physiology (1985); (United States) Vol. 72:2; ISSN 8750-7587; ISSN JAPHE
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACROLEIN
AEROSOLS
ALDEHYDES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD PRESSURE
BODY
BODY FLUIDS
COLLOIDS
DISPERSIONS
DOMESTIC ANIMALS
EDEMA
FORMALDEHYDE
INHALATION
INTAKE
LUNGS
LYMPH
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PROTEINS
RESIDUES
RESPIRATORY SYSTEM
RUMINANTS
SHEEP
SMOKES
SOLS
SYMPTOMS
TOXICITY
VERTEBRATES