Reperfusion pulmonary edema

Journal Article · Fri Feb 17 04:00:00 EST 1989 · JAMA, Journal of the American Medical Association; (USA)

DOI:https://doi.org/10.1001/jama.261.7.1030· OSTI ID:5640332

Klausner, J M; Paterson, I S; Mannick, J A; Valeri, C R; Shepro, D; Hechtman, H B ^[1]

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1. Harvard Medical School, Boston, MA (USA)

Reperfusion following lower-torso ischemia in humans leads to respiratory failure manifest by pulmonary hypertension, hypoxemia, and noncardiogenic pulmonary edema. The mechanism of injury has been studied in the sheep lung lymph preparation, where it has been demonstrated that the reperfusion resulting in pulmonary edema is due to an increase in microvascular permeability of the lung to protein. This respiratory failure caused by reperfusion appears to be an inflammatory reaction associated with intravascular release of the chemoattractants leukotriene B{sub 4} and thromboxane. Histological studies of the lung in experimental animals revealed significant accumulation of neutrophils but not platelets in alveolar capillaries. The authors conclude that thromboxane generated and released from the ischemic tissue is responsible for the transient pulmonary hypertension. Second, it is likely that the chemoattractants are responsible for leukosequestration, and third, neutrophils, oxygen-derived free radicals, and thromboxane moderate the altered lung permeability.

• OSTI ID: 5640332
• Journal Information: JAMA, Journal of the American Medical Association; (USA), Journal Name: JAMA, Journal of the American Medical Association; (USA) Vol. 261:7; ISSN 0098-7484; ISSN JAMAA
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOMEDICAL RADIOGRAPHY
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
DIAGNOSTIC TECHNIQUES
DISEASES
DOMESTIC ANIMALS
DRUGS
EDEMA
HISTOLOGY
HYPERTENSION
ISCHEMIA
LEUKOCYTES
LUNGS
LYMPH
MAMMALS
MATERIALS
MEDICINE
NUCLEAR MEDICINE
ORGANS
PATHOGENESIS
PATHOLOGICAL CHANGES
PERFUSED TISSUES
PERMEABILITY
RADIOLOGY
RESPIRATORY SYSTEM
RUMINANTS
SHEEP
SYMPTOMS
TISSUES
VASCULAR DISEASES
VASOCONSTRICTORS
VERTEBRATES