Copper, zinc superoxide dismutase (Cu, ZnSOD) and manganese superoxide dismutase (MnSOD): Developmental changes in erythroleukemia cells (ELC)

Conference · Sun Mar 10 23:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5374422

Yano, S; Clerch, L; Massaro, D ^[1]

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1. Georgetown Univ., Washington, DC (United States)

Increased Cu, ZnSOD activity in a clone of ELC has been attributed to the increased production of O{sub 2} due to auto-oxidation of a differentiation-associated rise in hemoglobin (Hb). The authors now show Cu, ZnSOD and MnSOD activity increase in ELC lone S9 without a rise in Hb content; the rise of Cu,ZnSOD activity but not MnSOD activity is blunted by a daily change of medium. In ELC clone DIB, Cu,ZnSOD but not MnSOD activity increases in culture. They conclude (1) the SODs an increase in ELC cells without a rise in Hb; (2) Cu, ZnSOD and MnSOD activity may not change coordinately; and (3) these clones should be useful to study the regulation of SOD gene expression.

• OSTI ID: 5374422
• Report Number(s): CONF-9104107--
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Vol. 5:4; ISSN FAJOE; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
CARBOXYLIC ACIDS
CELL CULTURES
CELL DIFFERENTIATION
CLONE CELLS
COPPER
ELEMENTS
ENZYME ACTIVITY
ENZYMES
GENE REGULATION
GLOBINS
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
MANGANESE
METABOLISM
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDOREDUCTASES
PIGMENTS
PORPHYRINS
PROTEINS
SUPEROXIDE DISMUTASE
TRANSITION ELEMENTS
TUMOR CELLS
ZINC