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Ethanol suppresses T cell proliferation without inhibiting interleukin 2 (IL2) production and IL2 receptor (IL2R) expression

Conference · · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)
OSTI ID:5372544
;  [1]
  1. VA Medical Center, West Los Angeles, CA (United States) Univ. of California, Los Angeles (United States)
+ Show Author Affiliations
The effect of extended ethanol consumption of young C57BL/6J mice on T cell proliferation was studied. Splenic cells of young mice, fed with one of three different liquid diets for 6-7 weeks were cultured with Con A to assess T cell proliferation and production of IL2. Then, the proliferative response of splenic cells to PMA/ionomycin was assessed. Finally, Con A-activated T blast cells were assessed for their ability to express IL2R and to respond to IL2. The results showed that both Con A-induced mitogenesis and IL2-dependent proliferation of T cells from ethanol diet-fed mice were diminished as compared to that of maltose-substitute diet or standard liquid diet. However, the ability of T cells from ethanol diet-fed mice to produce IL2 and to express IL2R was not affected. Furthermore, the magnitude of ethanol-mediated suppression of T cell proliferation induced by PMA/ionomycin was comparable to that induced by Con A. These results taken together suggest that ethanol suppresses T cell proliferation by interfering with events following the IL2-IL2R interaction.
OSTI ID:
5372544
Report Number(s):
CONF-9104107--
Conference Information:
Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 5:4
Country of Publication:
United States
Language:
English

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Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGGLUTININS
ALCOHOLS
ANIMAL CELLS
ANIMALS
ANTIBODIES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL PROLIFERATION
CONCANAVALIN A
CONNECTIVE TISSUE CELLS
ETHANOL
GROWTH FACTORS
HEMAGGLUTININS
HYDROXY COMPOUNDS
LECTINS
LEUKOCYTES
LYMPHOCYTES
LYMPHOKINES
MAMMALS
MATERIALS
MEMBRANE PROTEINS
MICE
MITOGENS
ORGANIC COMPOUNDS
PROTEINS
RECEPTORS
RODENTS
SOMATIC CELLS
SPLEEN CELLS
SYNTHESIS
VERTEBRATES