Cadmium and zinc relationships in kidney cortex, liver, and pancreas
Journal Article
·
· Environ. Res.; (United States)
Zinc and cadmium have been determined in kidney cortex, liver, and pancreas from 292 subjects autopsied in Stockholm, Sweden. In the liver and pancreas zinc was found to have a normal frequency distribution, average 45.3 ..mu..g/g and 26.9 ..mu..g/g wet wt, respectively. The concentrations of zinc in these two organs were constant regardless of age at death. Zinc was shown to accumulate with age in the kidney cortex in a way similar to cadmium, and had a log-normal distribution. The calculation of the regression line between individual cadmium concentrations below 60 ..mu..g/g and zinc concentrations gave a slope constant of 0.61 (Y/sub Zn/ = 0.61 X/sub Cd/ + 24.4), which corresponds to a nearly equimolar increase of zinc. The concentrations of ''physiological zinc,'' i.e., total zinc minus the zinc related to cadmium, were normally distributed (anti x = 24.6 ..mu..g Zn/g) and did not change with age. Furthermore, data on dry weight/wet weight ratios and ash weight/dry weight ratios in relation to age are presented.
- Research Organization:
- Karolinska Inst., Stockholm
- OSTI ID:
- 5370610
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 13:3; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550500 -- Metabolism
552000 -- Public Health
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
AGE GROUPS
BIOLOGICAL ACCUMULATION
BODY
CADMIUM
DIGESTIVE SYSTEM
ELEMENTS
ENDOCRINE GLANDS
EUROPE
GLANDS
KIDNEYS
LIVER
METALS
ORGANS
PANCREAS
SCANDINAVIA
SWEDEN
ZINC
552000 -- Public Health
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
AGE GROUPS
BIOLOGICAL ACCUMULATION
BODY
CADMIUM
DIGESTIVE SYSTEM
ELEMENTS
ENDOCRINE GLANDS
EUROPE
GLANDS
KIDNEYS
LIVER
METALS
ORGANS
PANCREAS
SCANDINAVIA
SWEDEN
ZINC