Positron imaging in ischemic stroke disease using compounds labeled with oxygen 15. Initial results of clinicophysiologic correlations

Journal Article · Tue Sep 01 00:00:00 EDT 1981 · Arch. Neurol.; (United States)

DOI:https://doi.org/10.1001/archneur.1981.00510090031002· OSTI ID:5367509

Ackerman, R H; Correia, J A; Alpert, N M; Baron, J C; Gouliamos, A; Grotta, J C; Brownell, G L; Taveras, J M

Initial results in over 50 patients with stroke suggest that positron images made during continuous inhalation of carbon dioxide labeled with oxygen 15 and molecular oxygen labeled with oxygen 15 provide data on tissue function that may be relevant to acute stroke management. Five cases illustrate the following findings: 15O-activity patterns observed in areas of ischemic injury or infarction are what one would expect if the 15O distributions represented physiologic functions, such as cerebral blood flow and metabolism. Areas of abnormal 15O activity correlate with the clinical or computed tomographic (CT) localization of the deficit. In studies performed acutely, changes in 15O distributions anticipate alterations in CT scans and may be predictive of outcome. Data related to oxygen metabolism correlate better with tissue viability than do those reflecting cerebral blood flow.

• OSTI ID: 5367509
• Journal Information: Arch. Neurol.; (United States), Vol. 38:9
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
BRAIN
SCINTISCANNING
ISCHEMIA
DIAGNOSIS
OXYGEN 15
DIAGNOSTIC USES
VASCULAR DISEASES
BLOOD FLOW
CARBON DIOXIDE
INHALATION
LABELLED COMPOUNDS
METABOLISM
OXYGEN
PATHOLOGY
PATIENTS
PHYSIOLOGY
POSITRON COMPUTED TOMOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON COMPOUNDS
CARBON OXIDES
CARDIOVASCULAR DISEASES
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
ELEMENTS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
INTAKE
ISOTOPES
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NONMETALS
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
RADIOISOTOPE SCANNING
RADIOISOTOPES
TOMOGRAPHY
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550901 - Pathology- Tracer Techniques
551001 - Physiological Systems- Tracer Techniques