Analysis of the effects of chemical and physical mutagens on subchromosomal DNA synthesis in cultured mammalian cells. [X rays; uv radiation; MMS]
Technical Report
·
OSTI ID:5366519
Subchromosomal DNA synthesis in Chinese hamster V-79 cells exposed to methyl methanesulfonate (MMS), x radiation, and ultraviolet (uv) radiation was investigated. The results indicate that these agents disturb DNA synthesis at the replicon level via two mechanisms of action, inhibition of replicon initiation or transient blockage of DNA chain growth. Exposure to uv or to MMS effects both DNA chain growth and initiation. In contrast, the depression in DNA synthetic rate in x-irradiated cells is due exclusively to inhibition of replicon initiation. For the most part, the damage inflicted upon the DNA synthetic apparatus produced by the three agents is repairable. The inhibition of replicon initiation produced by each of the three agents studied appears to be a complex metabolic phenomenon, and speculation regarding several mechanisms by which replicon initiation may be inhibited is elaborated upon in the text. (ERB)
- Research Organization:
- Rochester Univ., NY (USA). Dept. of Radiation Biology and Biophysics
- DOE Contract Number:
- AC02-76EV03490
- OSTI ID:
- 5366519
- Report Number(s):
- UR-3490/LCP-20
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201 -- Biochemistry-- Tracer Techniques
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL CULTURES
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DNA
DNA REPLICATION
ELECTROMAGNETIC RADIATION
ESTERS
EXPERIMENTAL DATA
INFORMATION
INHIBITION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
METHYL METHANESULFONATE
MUTAGENS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
SULFONIC ACID ESTERS
ULTRAVIOLET RADIATION
X RADIATION
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL CULTURES
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DNA
DNA REPLICATION
ELECTROMAGNETIC RADIATION
ESTERS
EXPERIMENTAL DATA
INFORMATION
INHIBITION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
METHYL METHANESULFONATE
MUTAGENS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
SULFONIC ACID ESTERS
ULTRAVIOLET RADIATION
X RADIATION