Peptide YY receptors in the brain

Journal Article · Fri Jan 15 04:00:00 EST 1988 · Biochem. Biophys. Res. Commun.; (United States)

DOI:https://doi.org/10.1016/0006-291X(88)90481-0· OSTI ID:5363339

Inui, A; Oya, M; Okita, M; Inoue, T; Sakatani, N; Morioka, H; Shii, K; Yokono, K; Mizuno, N; Baba, S

Radiolabelled ligand binding studies demonstrated that specific receptors for peptide YY are present in the porcine as well as the canine brains. Peptide YY was bound to brain tissue membranes via high-affinity (dissociation constant, 1.39 X 10(-10)M) and low-affinity (dissociation constant, 3.72 X 10(-8)M) components. The binding sites showed a high specificity for peptide YY and neuropeptide Y, but not for pancreatic polypeptide or structurally unrelated peptides. The specific activity of peptide YY binding was highest in the hippocampus, followed by the pituitary gland, the hypothalamus, and the amygdala of the porcine brain, this pattern being similarly observed in the canine brain. The results suggest that peptide YY and neuropeptide Y may regulate the function of these regions of the brain through interaction with a common receptor site.

• Research Organization: Kobe Univ., Japan
• OSTI ID: 5363339
• Journal Information: Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 150:1; ISSN BBRCA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOCHEMICAL REACTION KINETICS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DISTRIBUTION
DOGS
DOMESTIC ANIMALS
ENDOCRINE GLANDS
GLANDS
HIPPOCAMPUS
HYPOTHALAMUS
KINETICS
LIGANDS
MAMMALS
MEMBRANE PROTEINS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PEPTIDES
PITUITARY GLAND
PROTEINS
REACTION KINETICS
RECEPTORS
SPECIFICITY
SWINE
THALAMUS
TISSUE DISTRIBUTION
VERTEBRATES