Postnatal changes in local cerebral blood flow measured by the quantitative autoradiographic ( sup 14 C)iodoantipyrine technique in freely moving rats

Journal Article · Sun Oct 01 00:00:00 EDT 1989 · Journal of Cerebral Blood Flow and Metabolism; (USA)

DOI:https://doi.org/10.1038/jcbfm.1989.83· OSTI ID:5359141

Nehlig, A; Pereira de Vasconcelos, A; Boyet, S ^[1]

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1. INSERM U272, Nancy (France)

The postnatal changes in local cerebral blood flow in freely moving rats were measured by means of the quantitative autoradiographic ({sup 14}C)iodoantipyrine method. The animals were studied at 10, 14, 17, 21 and 35 days and at the adult stage. At 10 days after birth, rates of blood flow were very low and quite homogeneous in most cerebral structures except in a few posterior areas. From these relatively uniform levels, values of local cerebral blood flow rose notably to reach a peak at 17 days in all brain regions studied. Rates of blood flow decreased between 17 and 21 days after birth and then increased from weaning time to reach the known characteristic distribution of the adult rat. The postnatal evolution of local cerebral blood in the rat is in good agreement with previous studies in other species such as dog and humans that also show higher rates of cerebral blood flow and glucose utilization at immature stages. However, in the rat, local cerebral blood flow and local cerebral glucose utilization are not coupled over the whole postnatal period studied, since blood flow rates reach peak values at 17 days whereas glucose utilization remains still quite low at that stage. The high rate of cerebral blood flow in the 17-day-old rat may reflect the energetic and biosynthetic needs of the actively developing brain that are completed by the summation of glucose and ketone body utilization.

• OSTI ID: 5359141
• Journal Information: Journal of Cerebral Blood Flow and Metabolism; (USA), Vol. 9:5; ISSN 0271-678X
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CEREBRAL CORTEX
BLOOD FLOW
GLUCOSE
METABOLISM
AGE DEPENDENCE
ANTIPYRINE
AUTORADIOGRAPHY
CARBON 14 COMPOUNDS
RATS
ALDEHYDES
ANIMALS
ANTIPYRETICS
AZOLES
BODY
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CEREBRUM
DRUGS
HETEROCYCLIC COMPOUNDS
HEXOSES
LABELLED COMPOUNDS
MAMMALS
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRAZOLES
PYRAZOLINES
RODENTS
SACCHARIDES
VERTEBRATES
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