In Vitro and in vivo antitumor effects of pepleomycin alone or in combination with radiation

Journal Article · Wed May 01 00:00:00 EDT 1985 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576469· OSTI ID:5355675

Sakamoto, K; Komatsu, K; Matsumoto, Y

Pepleomycin is a derivative of bleomycin, which is less toxic to the host but possesses greater antitumor activity. Experiments are described herein which Chinese hamster V-79 cells in culture and a murine squamous cell carcinoma in vivo have been used to obtain survival curves for pepleomycin alone or in combination with radiation. In both systems the survival curves for pepleomycin alone are diphasic, and this drug proved to be twice as effective as bleomycin. Further, in contrast to bleomycin, which showed simple additivity with radiation, pepleomycin potentiated radiation injury to the tumor cells both in vivo and in vitro. Therefore, pepleomycin may be superior to bleomycin not only in drug therapy but also in combined modality therapy.

• Research Organization: Tohoku Univ. School of Medicine, Sendai, Japan
• OSTI ID: 5355675
• Journal Information: Radiat. Res.; (United States), Vol. 102:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIMITOTIC DRUGS
RADIOSENSITIVITY EFFECTS
CELL KILLING
RADIOINDUCTION
FIBROBLASTS
BIOLOGICAL RADIATION EFFECTS
TUMOR CELLS
ANTIBIOTICS
BLEOMYCIN
CARCINOMAS
EXPERIMENTAL NEOPLASMS
HAMSTERS
IN VITRO
IN VIVO
MICE
SURVIVAL CURVES
X RADIATION
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
CONNECTIVE TISSUE CELLS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MAMMALS
NEOPLASMS
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)