Deuterium nuclear magnetic resonance measurements of blood flow and tissue perfusion employing /sup 2/H/sub 2/O as a freely diffusible tracer
The use of deuterium oxide (/sup 2/H/sub 2/O) is proposed as a freely diffusible nuclear magnetic resonance (NMR) blood flow and tissue perfusion tracer of potential clinical utility. Deuterium is a stable, nonradiative isotope commercially available as /sup 2/H/sub 2/O at enrichment levels of essentially 100%-i.e., 110 molar equivalent deuterium. This high concentration, together with the short relaxation time of the spin 1 (quadrupole) deuterium nuclide, provides substantial sensitivity for NMR spectroscopy. As a result, when /sup 2/H/sub 2/O is administered in a bolus fashion to a specific tissue or organ in vivo, the deuterium NMR intensity time course can be analyzed, using mathematical models developed by others for radiolabeled tracers, to measure the rate of blood flow and tissue perfusion. Such an application is demonstrated herein at a static magnetic field of 8.5 tesla. Using single-compartment flow modeling, hepatic blood flow and tissue perfusion in fasted (18 hr) male Sprague-Dawley rats was determined to be 61 +/- 17 (mean +- SD) ml/100 g per min (n = 5).
- Research Organization:
- Washington Univ. School of Medicine, St. Louis
- OSTI ID:
- 5354035
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 84:12; ISSN PNASA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
ANIMALS
BLOOD FLOW
BODY
DIGESTIVE SYSTEM
DYNAMIC FUNCTION STUDIES
GLANDS
HEAVY WATER
HYDROGEN COMPOUNDS
IN VIVO
ISOTOPE APPLICATIONS
LIVER
MAGNETIC RESONANCE
MAMMALS
MATHEMATICAL MODELS
NUCLEAR MAGNETIC RESONANCE
ORGANS
OXYGEN COMPOUNDS
PERFUSED TISSUES
RATS
RELAXATION
RESONANCE
RODENTS
SPIN-LATTICE RELAXATION
TISSUES
TRACER TECHNIQUES
VERTEBRATES
WATER