A deuterium nuclear magnetic resonance spectroscopic investigation of tumor blood flow in vivo
Thesis/Dissertation
·
OSTI ID:5129715
Deuterium nuclear magnetic resonance (NMR) spectroscopic techniques have been developed and applied to quantify tumor blood flow and perfusion in vivo. Deuterium NMR was employed to monitor the deuterium residue in tumor over time following direct intratumor injection of D{sub 2}O as a freely diffusible tracer. The deuterium washout time course was analyzed by multicompartment flow models, which were developed and validated in blood flow determinations of subcutaneous murine radiation-induced fibrosarcomas (RIF-1) grown on female C3H mice. These multicompartment flow models, two-compartment in-series and three-compartment flow models, can account for tracer recirculation. Using the {sup 2}H NMR flow measurement technique, the hyperglycemia-induced modulation of tumor blood flow as monitored following intraperitoneal injection of glucose, mannitol, 3-O-methyl-D-glucose, and saline solution.
- Research Organization:
- Washington Univ., St. Louis, MO (USA)
- OSTI ID:
- 5129715
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ANIMAL TISSUES
ANIMALS
BLOOD FLOW
BODY
CARBOHYDRATES
DEUTERIUM
EXPERIMENTAL NEOPLASMS
GLUCOSE
HEXOSES
HYDROGEN ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAGNETIC RESONANCE
MAMMALS
MATHEMATICAL MODELS
MICE
MONOSACCHARIDES
NMR SPECTRA
NUCLEAR MAGNETIC RESONANCE
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PERFUSED TISSUES
RESONANCE
RODENTS
SACCHARIDES
SPECTRA
STABLE ISOTOPES
TISSUES
TRACER TECHNIQUES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ANIMAL TISSUES
ANIMALS
BLOOD FLOW
BODY
CARBOHYDRATES
DEUTERIUM
EXPERIMENTAL NEOPLASMS
GLUCOSE
HEXOSES
HYDROGEN ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAGNETIC RESONANCE
MAMMALS
MATHEMATICAL MODELS
MICE
MONOSACCHARIDES
NMR SPECTRA
NUCLEAR MAGNETIC RESONANCE
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PERFUSED TISSUES
RESONANCE
RODENTS
SACCHARIDES
SPECTRA
STABLE ISOTOPES
TISSUES
TRACER TECHNIQUES
VERTEBRATES