Radioprotection of the rat parotid gland by WR-2721 and isoproterenol and its modification by propranolol
The aminothiol WR-2721 and ..beta..-adrenergic agonist isoproterenol both conferred considerable radioprotection to the rat parotid gland. Isoproterenol acts on the ..beta..-receptor, and its specific antagonist, propranolol, eliminated isoproterenol's protective effect, implicating the ..beta..-receptor and possibly cAMP in the mechanism of the protection. Since other sulfhydryl-containing protectants have been shown to elevate cAMP it was reasoned that WR-2721 might do so as well. However, the radioprotection conferred by WR-2721 was not reduced by propranolol, showing that the ..beta..-receptor played no part in WR-2721's action. The possible role of cAMP in radioprotection by isoproterenol is discussed.
- Research Organization:
- Temple Univ. School of Medicine, Philadelphia, PA
- OSTI ID:
- 5347848
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 94:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Radioprotection of the rat parotid gland by cAMP
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Related Subjects
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
AMINES
AMP
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CONDENSED AROMATICS
DATA
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
GLANDS
GLYCOLS
HYDROCARBONS
HYDROXY COMPOUNDS
INFORMATION
IONIZING RADIATIONS
MAMMALS
NAPHTHALENE
NUCLEOTIDES
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RATS
RECEPTORS
RODENTS
SALIVARY GLANDS
THIOLS
VERTEBRATES
X RADIATION