Antibody production in rats after long-term exposure to formaldehyde
Journal Article
·
· Toxicology and Applied Pharmacology; (USA)
- Karolinska Institutet (Sweden)
Sprague-Dawley rats were vaccinated with pneumococcal polysaccharide antigens and tetanus toxoid to evaluate the immunologic effects of long-term formaldehyde exposure. The antibody response to vaccination was measured 3 to 4 weeks later by enzyme-linked immunosorbent assay. An IgG response to pneumococcal polysaccharides and to tetanus toxoid was found in both the formaldehyde-exposed group and a control group of rats not exposed to formaldehyde. The IgM response to tetanus toxoid was significant in both groups but neither group showed a significant IgM response to pneumococcal polysaccharides. There were thus no signs of impaired B-cell function in rats exposed to a high concentration (12.6 ppm) of formaldehyde for nearly 2 years.
- OSTI ID:
- 5346203
- Journal Information:
- Toxicology and Applied Pharmacology; (USA), Journal Name: Toxicology and Applied Pharmacology; (USA) Vol. 100:2; ISSN TXAPA; ISSN 0041-008X
- Country of Publication:
- United States
- Language:
- English
Similar Records
Evaluation of the humoral immune response of children with low level lead exposure
Use of total lymphoid irradiation (TLI) in studies of the T cell dependence of autoantibody production in rheumatoid arthritis
Effect of total lymphoid irradiation on levels of serum autoantibodies in systemic lupus erythematosus and in rheumatoid arthritis
Journal Article
·
Thu Jul 01 00:00:00 EDT 1976
· Bull. Environ. Contam. Toxicol.; (United States)
·
OSTI ID:7327713
Use of total lymphoid irradiation (TLI) in studies of the T cell dependence of autoantibody production in rheumatoid arthritis
Journal Article
·
Tue Jan 31 23:00:00 EST 1984
· J. Immunol.; (United States)
·
OSTI ID:5071920
Effect of total lymphoid irradiation on levels of serum autoantibodies in systemic lupus erythematosus and in rheumatoid arthritis
Journal Article
·
Tue Dec 31 23:00:00 EST 1985
· Arthritis Rheum.; (United States)
·
OSTI ID:5633420
Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMAL CELLS
ANIMALS
ANTIBODY FORMATION
ANTIGENS
BACTERIA
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOHYDRATES
CHRONIC EXPOSURE
CONNECTIVE TISSUE CELLS
ENZYME IMMUNOASSAY
FORMALDEHYDE
FUNCTIONS
IMMUNE REACTIONS
IMMUNOASSAY
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICROORGANISMS
ORGANIC COMPOUNDS
PNEUMOCOCCUS
POLYSACCHARIDES
RATS
RODENTS
SACCHARIDES
SOMATIC CELLS
TOXIC MATERIALS
TOXINS
VACCINES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMAL CELLS
ANIMALS
ANTIBODY FORMATION
ANTIGENS
BACTERIA
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOHYDRATES
CHRONIC EXPOSURE
CONNECTIVE TISSUE CELLS
ENZYME IMMUNOASSAY
FORMALDEHYDE
FUNCTIONS
IMMUNE REACTIONS
IMMUNOASSAY
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICROORGANISMS
ORGANIC COMPOUNDS
PNEUMOCOCCUS
POLYSACCHARIDES
RATS
RODENTS
SACCHARIDES
SOMATIC CELLS
TOXIC MATERIALS
TOXINS
VACCINES
VERTEBRATES