Biological effects summary report di(2-ethylhexyl) sebacate

Technical Report · Sat Oct 01 00:00:00 UTC 1983

OSTI ID:5346077

Silverstein, B D; White, O Jr; Brower, J E; Bernholc, N M

An evaluation of the health effects of di(2-ethylhexyl) sebacate (DEHS) was made to assess its potential use as substitute for di(2-ethylhexyl) phthalate (DEHP), which is used as a test aerosol in quantitative fit testing of respirators. A review of published and unpublished information on toxicity of DEHS was made. The limited amount of data on DEHS indicated that it has a low level of toxicity to laboratory animals. No oral or inhalation toxicity studies on humans were found, but skin sensitization and irritation studies were negative. Insufficeint data exists at present to permit determination of DEHS carcinogenicity. Because of structural similarities of DEHS to DEHP and di(ethylhexyl) adipate, and because these latter two materials have been shown to be carcinogenic in rats and mice, DEHS is not recommended at this time as a DEHP substitute until lack of its carcinogenic potential is confirmed.

• Research Organization: Brookhaven National Lab., Upton, NY (USA)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 5346077
• Report Number(s): BNL-51729; ON: DE84005624
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ANIMALS
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
CARCINOGENESIS
DICARBOXYLIC ACIDS
ESTERS
INHALATION
INTAKE
MAMMALS
METABOLISM
MICE
NATIONAL ORGANIZATIONS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PATHOGENESIS
PLASTICIZERS
RATS
RODENTS
SEBACIC ACID
SKIN EFFECT
US DOL
US ORGANIZATIONS
US OSHA
VERTEBRATES