Health hazards associated with the use of di-(2-ethylhexyl) phthalate (commonly referred to as DOP) in HEPA filter test
Di-(2-ethylhexyl) phthalate (DEHP), commonly referred to as di-octyl phthalate, is an important production chemical in the US. In addition to its major use as an additive in plastics, DEHP is widely used to evaluate the effectiveness of high efficiency particulate air (HEPA) filters. Historically, DEHP was also used in quantitative fit testing for respirators. Evaluations of this compound a decade ago showed that it can induce hepatocellular carcinomas in laboratory animals. Although most Department of Energy (DOE) facilities have since discontinued using DEHP in respirator fit testing, DEHP continues to be used for evaluating HEPA filters. This report summarizes available information on the toxicity, mutagenicity, carcinogenicity, and other hazards and problems posed by DEHP, specifically with reference to HEPA filter testing. Information on work practice improvements as well as the availability and suitability of DEHP substitutes are also presented. This material should assist the DOE in the safe use of this material.
- Research Organization:
- USDOE Assistant Secretary for Environment, Safety, and Health, Washington, DC (United States)
- Sponsoring Organization:
- USDOE, Washington, DC (United States); USDOE Assistant Secretary for Environment, Safety, and Health, Washington, DC (United States)
- OSTI ID:
- 57618
- Report Number(s):
- DOE/EH-0440; ON: DE95010792
- Resource Relation:
- Other Information: PBD: Jan 1995
- Country of Publication:
- United States
- Language:
- English
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