New osmium-191/iridium-191m radionuclide generator system using activated carbon

Journal Article · Fri Feb 28 23:00:00 EST 1986 · J. Nucl. Med.; (United States)

OSTI ID:5342009

Brihaye, C; Butler, T A; Knapp, Jr, F F; Guillaume, M; Watson, E E; Stabin, M G

A new osmium-191/iridium-191m (191Os/191mIr) radionuclide generator system has been developed based on the absorption of K2OsCl6 (Os-IV) on 140-230 mesh heat-treated activated carbon. The generator is eluted with pH 2 saline solution containing 0.25 g/l Kl to give 191mIr in good yield. The generator eluent is neutralized to physiologic pH and isotonicity with Tris buffer immediately prior to i.v. injection. No scavenger column is required. As an example, elution of the prototype generator with a 2-ml bolus results in elution of 191mIr in approximately 18% yield with an 191Os breakthrough of only 2 X 10(-4)%/bolus. The prototype generator has consistent performance over a 2-wk period with no change in 191mIr yield or 191Os breakthrough. Loading of up to 1.5 Ci of 191Os results in no observed radiolysis. Continuous elution of this system is also possible with a mean 191mIr yield of 3.7%/ml and a mean 191Os breakthrough of 2 X 10(-5)%/ml at a flow rate of 12 ml/min. This new system represents a readily available source of 191mIr for radioangiography. Adsorbed radiation dose calculations indicate a total-body dose of only 3.9 mrad for a 100 mCi injected bolus.

• Research Organization: Oak Ridge National Lab., TN
• OSTI ID: 5342009
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 3; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703* -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ACTIVATED CARBON
ADSORBENTS
ADSORPTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBON
DAYS LIVING RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IRIDIUM 191
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE PRODUCTION
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
OSMIUM 191
OSMIUM ISOTOPES
RADIOISOTOPE GENERATORS
RADIOISOTOPES
RATS
RODENTS
SECONDS LIVING RADIOISOTOPES
SORPTION
STABLE ISOTOPES
VERTEBRATES