Skin radiosensitization studies using combined cis-dichlorodiammineplatinum (II) and radiation
Conference
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:5339455
Cis-dichlorodiammineplatinum(II) (cis-DDP) has been shown to interact with radiation, resulting in an apparent potentiation of radiation damage. Since the skin is a major tissue for the uptake of cis-DDP and platinum levels persist in human skin for several days, experiments were designed to evaluate the potential for enhanced normal tissue damage in rats and humans following combined platinum-radiotherapy. The results of these experiments suggest that a cis-DDP dose of 2.5 mg/kg produces an increase in damage to both irradiated hypoxic and well-oxygenated skin. This effect was observed regardless of whether the drug was administered IP 2 hours before, or immediately after, irradiation.
- Research Organization:
- Dartmouth-Hitchcock Medical Center, Hanover, NH
- OSTI ID:
- 5339455
- Conference Information:
- Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:8
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
560152 -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANOXIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COMPLEXES
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
MAMMALS
NUMERICAL DATA
ORGANS
PATIENTS
PLATINUM COMPLEXES
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SKIN
TIME DEPENDENCE
TRANSITION ELEMENT COMPLEXES
UPTAKE
VERTEBRATES
X RADIATION
560151* -- Radiation Effects on Animals-- Man
560152 -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANOXIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COMPLEXES
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
MAMMALS
NUMERICAL DATA
ORGANS
PATIENTS
PLATINUM COMPLEXES
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SKIN
TIME DEPENDENCE
TRANSITION ELEMENT COMPLEXES
UPTAKE
VERTEBRATES
X RADIATION