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Effect of cis-platinum on the repair of radiation damage in plateau phase Chinese hamster (V-79) cells

Conference · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:5276020
; ;
The interaction of cis-dichlorodiammine platinum (II) (cis-DDP) with irradiation may be important in the clinical settings for which this drug is currently used. We have approached this problem by observing the effect of cis-DDP on repair of sublethal radiation damage (SLD) and potentially lethal radiation damage (PLD). Fed plateau phase Chinese hamster (V-79) cells were pretreated with cis-DDP for 2 hours prior to irradiation and for varying intervals after irradiation in single dose and two dose repair experiments. For drug concentrations of 5 ..mu..M and 10..mu..M (minimally toxic doses), inhibition of repair was observed in a split dose experiment. Repair of PLD was inhibited only minimally in the presence of cis-platinum in single dose experiments. This selective drug radiation interaction suggests that simultaneous combinations of platinum with radiation may result in altered biological effects of radiation.
Research Organization:
Tufts-New England Medical Center Hospital, Boston, MA
OSTI ID:
5276020
Conference Information:
Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:8
Country of Publication:
United States
Language:
English

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Related Subjects

550300 -- Cytology
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL CULTURES
COMPLEXES
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
FIBROBLASTS
HAMSTERS
INFORMATION
INHIBITION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
MAMMALS
NUMERICAL DATA
PLATINUM COMPLEXES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
RODENTS
SOMATIC CELLS
SURVIVAL CURVES
TIME DEPENDENCE
TRANSITION ELEMENT COMPLEXES
VERTEBRATES
X RADIATION