Toxic variability and radiation sensitization by dichlorodiammineplatinum(II) complexes in Salmonella typhimurium cells

Journal Article · Sat Sep 01 04:00:00 EDT 1984 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576334· OSTI ID:6411859

Richmond, R C

The oxidative coordination compound cis-dichlorodiammineplatinum(II) (cis-DDP) is again shown to be a hypoxic cell radiation sensitizer. The mechanism of cis-DDP-induced radiation sensitization is complex. Results here indicate that cis-DDP sensitization operates in part through reactive free radicals, in part through the interactions of radiation-induced reactive Pt(I) intermediates, and in part through the involvement of thermodynamic and kinetic aspects of Pt(II)-DNA binding during irradiation. For the first time, radiation sensitization by trans-DDP is compared with a sensitizing concentration of cis-DDP within the same study. Both analogs are sensitizers, but with significant differences. Further, irradiated hypoxic solutions of cis-DDP are found to be more toxic than unirradiated solutions.

• Research Organization: Dartmouth-Hitchcock Medical Center, Hanover, NH
• OSTI ID: 6411859
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 99:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

550700 -- Microbiology
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL KILLING
COMPLEXES
DNA
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MICROORGANISMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PLATINUM COMPLEXES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
REACTION INTERMEDIATES
SALMONELLA
SALMONELLA TYPHIMURIUM
TOXICITY
TRANSITION ELEMENT COMPLEXES
X RADIATION