Quantitative observations of the subacute effects of x irradiation on brain capillary permeability. Part III

Conference · Sat Sep 01 04:00:00 EDT 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:5339083

Edwards, M S; Levin, V A; Byrd, A

Male Fischer 344 rats received cerebral irradiation at 300 rad/day, four days/wk for three wk, to a total dose of 3600 rad. The capillary permeability coefficients for galactitol, urea, and sodium determined at 6, 10, and 12 wk postirradiation were not statistically different when they were compared to control rats. We found no evidence for the ''early'' delayed effects of x irradiation based on alteration of brain capillary permeability. We feel this syndrome is the result of alteration in the processes that control the maintenance of myelin. Further investigation of cellular and biochemical effects of irradiation would be more informative than additional capillary membrane studies.

• Research Organization: Univ. of California, San Francisco
• OSTI ID: 5339083
• Conference Information: Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:9
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
551001 -- Physiological Systems-- Tracer Techniques
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ALKALI METALS
AMIDES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD VESSELS
BODY
BRAIN
CAPILLARIES
CAPILLARY FLOW
CARBON 14
CARBON ISOTOPES
CARBONIC ACID DERIVATIVES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CEREBRUM
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DOSES
ELECTROMAGNETIC RADIATION
ELEMENTS
EVEN-EVEN NUCLEI
EXPERIMENTAL DATA
FLUID FLOW
FRACTIONATED IRRADIATION
HYDROGEN ISOTOPES
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
LOCAL IRRADIATION
MAMMALS
METALS
NERVOUS SYSTEM
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PERMEABILITY
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RATS
RODENTS
SECONDS LIVING RADIOISOTOPES
SODIUM
SODIUM 24
SODIUM ISOTOPES
TRACER TECHNIQUES
TRITIUM
UREA
VERTEBRATES
X RADIATION
YEARS LIVING RADIOISOTOPES