Quantitative observations of the acute effects of x-irradiation on brain capillary permeability. Part I
Rats were irradiated with single and multiple daily dose fractions of 200 to 2500 rad; the capillary permeability coefficients (P) for /sup 14/C-urea, /sup 3/H-glactitol, /sup 3/H-VM-26, and bleomycin were determined after completion of each course. The drugs have a wide range of molecular weights and lipophilicities. Radiation doses of 200 rad x 5 days and 400 rad x 1 day increased the urea P 14 to 32%, while other dose fractions had no effect on P. The P for galactitol was increased more consistently (52 to 116%) by single and multiple 200 rad fractions and single fractions of 400 and 1000 rad. The P for galactitol paradoxically was reduced approximately 60% by 200 rad x 10 days and 2500 rad x 1 day fractions. Permeability to galactitol was determined at various times 3 to 24 hr after single radiation doses of 200, 400, and 1000 rad; at all times P was increased over nonirradiated animals. No radiation dose had an effect on the P for bleomycin. Except for a single fraction (400 rad x 1 day), the P for VM-26 was also unaffected by radiation, and in that instance the P was reduced from normal.
- Research Organization:
- Univ. of California, San Francisco
- OSTI ID:
- 5236302
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 5:9; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDES
ANIMALS
ANTIBIOTICS
ANTIMITOTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLEOMYCIN
BLOOD VESSELS
BODY
BRAIN
CAPILLARIES
CAPILLARY FLOW
CARBON 14
CARBON ISOTOPES
CARBONIC ACID DERIVATIVES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DRUGS
ELECTROMAGNETIC RADIATION
EVEN-EVEN NUCLEI
EXPERIMENTAL DATA
FLUID FLOW
FRACTIONATED IRRADIATION
HYDROGEN ISOTOPES
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LIGHT NUCLEI
MAMMALS
NERVOUS SYSTEM
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PERMEABILITY
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RATS
REACTION KINETICS
RODENTS
TRACER TECHNIQUES
TRITIUM
UREA
VERTEBRATES
X RADIATION
YEARS LIVING RADIOISOTOPES