Effects of irradiation on the vascularity of the rat lung (in Japanese)
Journal Article
·
· Nippon Igaku Hoshasen Gakkai Zasshi, v. 33, no. 15, pp. 412-417
OSTI ID:4367528
The effects of irradiation on the intravascular volume of rat lung were investigated with respect to change of intravascular volume with time after irradiation, the effect of the dose of irradiation, the influence of the quality of radiation, and the effect of fractionation of the dose. After a single irradiation with 1000 rad, applied locally to the lung, the intravascular volume increased significantly in 1 to 3 days and decreased again 7 to 14 days after irradiation. The effects of doses of 200 to 1000 rad were examined. Increase of the intravascular volume was observed following irradiation with doses of 400 rad or more and the increase was proportional to the dose applied. To examine the influence of the quality of radiation, animals were irradiated with 1000 rad of 200 KV x rays, /sup 60/Co gamma rays, 6 MV x rays, and 12 MeV electrons. The increases in intravascular volume following irradiation with /sup 60/Co gamma rays, 6 MV x rays, and 12 MeV electrons were almost the same, and were less than those in animals irradiated with 200 KV x rays. To study the effect of dose fractionation, a total dose of 1200 rad was applied in 4, 6, and 12 fractions over a period of 14 days and the intravascular volume was measured 1 and 2 weeks after the first irradiation. Results suggested that, when the overall time and total dose were constant, change in the intravascular volume decreased with increase in the number of fractionations. (auth)
- Research Organization:
- Tokushima Univ., Japan
- NSA Number:
- NSA-29-008038
- OSTI ID:
- 4367528
- Journal Information:
- Nippon Igaku Hoshasen Gakkai Zasshi, v. 33, no. 15, pp. 412-417, Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi, v. 33, no. 15, pp. 412-417; ISSN NHGZA
- Country of Publication:
- Japan
- Language:
- Japanese
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