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Combined therapy with an aziridine derivative NSC 200724 (AB182) and radiation on an experimental leukemia

Conference · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:5339070
; ; ;
0-(bis(2,3-dimethyl-l-aziridinyl)phosphinyl)-N-hydroxyurethane AB182, in combination with irradiation, was investigated in the P388 lymphocytic leukemia system. Combined modality effectiveness appeared to be associated with radiation dose and tumor stage. Cytotoxicity studies indicated that the drug alone was cytotoxic and potentiated cell killing when it was used in combination with radiation.
Research Organization:
Arthur D. Little, Inc., Cambridge, MA
OSTI ID:
5339070
Conference Information:
Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:9
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTINEOPLASTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL KILLING
COBALT 60
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
DISEASES
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
GAMMA RADIATION
HEMIC DISEASES
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKEMIA
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RODENTS
SOMATIC CELLS
SURVIVAL TIME
SYNERGISM
TOXICITY
TUMOR CELLS
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES