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Radiation potentiating effect of ethyl bis(2,2-dimethyl-l-aziridinyl) phosphinate (AB-163)

Conference · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:5275165
 [1]; ;
  1. Medical Coll. of Virginia, Richmond
+ Show Author Affiliations
Ethyl bis(2,2-dimethyl-l-aziridinyl) phosphinate (AB-163), a new tris(aziridinyl) phosphine oxide (TEPA) analogue, was tested in a murine P388 lymphocytic leukemia combination radiotherapy chemotherapy model. In this system, the combination was synergistic with results rivaling the best previously reported radiation drug combination results in this model. Three time intervals between the two modalities were tested. The optimum combination utilized AB-163 120 mg/kg four hours before 400 rad whole-body ..gamma..-radiation; this resulted in 50% survival at 100 days and 330% increased life span (ILS) for the remainder. Drug alone produced a maximum of 188% ILS (120 mg/kg) with one survivor while radiation alone gave 48% ILS (optimum 400 rad) with no survivors. These findings make AB-163 attractive for further investigation including clinical combined modality trials.
OSTI ID:
5275165
Conference Information:
Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:9
Country of Publication:
United States
Language:
English

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550603 -- Medicine-- External Radiation in Therapy-- (1980-)
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
ESTERS
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
GAMMA RADIATION
HEMIC DISEASES
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
LEUKEMIA
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
NEOPLASMS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PHOSPHINIC ACID ESTERS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
SOMATIC CELLS
SURVIVAL TIME
SYNERGISM
TIME DEPENDENCE
TOXICITY
VERTEBRATES
WHOLE-BODY IRRADIATION